Fatigue: Causes, Fixes, and What Really Works

When you feel fatigue, a persistent state of physical or mental exhaustion that doesn’t go away with rest. Also known as chronic tiredness, it’s not just being sleepy—it’s your body screaming for change. Millions ignore it, brushing it off as "just stress" or "not enough sleep." But real fatigue doesn’t vanish after a good night’s rest. It lingers, drains your focus, and makes even small tasks feel impossible.

Fatigue often ties into other health issues you might not connect. Low iron? That’s a common culprit. Thyroid problems? They can silently sap your energy. Medications like clozapine, an antipsychotic linked to fatigue as a side effect for schizophrenia, or even glimepiride, a diabetes drug that can cause low blood sugar and drowsiness, might be part of the problem. Even hormone shifts from menopause or testosterone drops can leave you feeling drained. And if you’re dealing with chemotherapy or chronic conditions like constipation or allergies, your body is working overtime just to keep up.

It’s not just medical causes. Poor sleep habits, constant stress, or even your diet—skipping meals, eating too much sugar, or not drinking enough water—can turn normal tiredness into full-blown fatigue. You might think coffee fixes it, but caffeine is a band-aid. True recovery needs to address the root. That’s why so many people find relief not by popping pills, but by adjusting their routines, testing for hidden deficiencies, or switching medications under a doctor’s guidance.

Below, you’ll find real comparisons and practical guides from people who’ve been there. Whether it’s figuring out if your fatigue links to hormone changes, understanding how exercise helps with stubborn constipation that drains energy, or learning which medications are most likely to leave you worn out—we’ve collected the no-fluff, evidence-backed info you need. No guesswork. Just clear answers.

How Dimethyl Fumarate Affects Sleep and Fatigue in Chronic Illness 18 October 2025

How Dimethyl Fumarate Affects Sleep and Fatigue in Chronic Illness

Explore how dimethyl fumarate influences sleep quality and fatigue in chronic illness, with evidence, benefits, side‑effects, and practical tips.