AIH Treatment: What It Is, How It Works, and What You Need to Know

When your immune system turns on your own liver, you’re dealing with autoimmune hepatitis, a chronic condition where the body’s defense system mistakenly attacks liver cells, causing inflammation and potential scarring. Also known as AIH, this disease doesn’t come from alcohol or viruses—it’s an internal mistake, and it needs targeted treatment to stop the damage before it becomes irreversible. Without proper care, AIH can lead to cirrhosis, liver failure, or even the need for a transplant. The good news? With the right immunosuppressants, medications that calm the overactive immune response to protect the liver, most people can live normal, healthy lives.

The main weapons in AIH treatment, the standard medical approach to controlling autoimmune hepatitis by suppressing harmful immune activity are corticosteroids like prednisone. These drugs work fast to reduce inflammation, but they’re not meant for long-term use alone because of side effects—weight gain, bone loss, high blood sugar. That’s why doctors usually add a second drug, like azathioprine or mycophenolate, to lower the steroid dose over time. It’s a balancing act: enough suppression to stop liver damage, but not so much that you’re vulnerable to infections. Regular blood tests to check liver enzymes, immune markers, and overall health are non-negotiable. This isn’t a one-time fix—it’s a long-term plan that changes as your body responds.

What you won’t find in most AIH treatment guides is how much lifestyle matters. While meds do the heavy lifting, cutting alcohol, avoiding liver-stressing supplements, and managing stress can make a real difference. Some people see their liver enzymes normalize within months. Others need adjustments for years. There’s no cure, but remission is common—and achievable. The key is sticking with your doctor’s plan, even when you feel fine. Liver damage doesn’t always cause symptoms until it’s advanced.

Below, you’ll find real-world insights from people managing this condition, from how to handle side effects of immunosuppressants to what to ask your pharmacist when switching medications. These aren’t theory pieces—they’re practical stories from patients and providers who’ve walked this path. Whether you’re newly diagnosed or have been on treatment for years, there’s something here that will help you take control.